Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

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第一作者： Sébastien J,Dumas

第一单位： Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium.

作者： Sébastien J,Dumas ^[1] ; Elda,Meta ^[2] ; Mila,Borri ^[1] ; Jermaine,Goveia ^[2] ; Katerina,Rohlenova ^[1] ; Nadine V,Conchinha ^[2] ; Kim,Falkenberg ^[1] ; Laure-Anne,Teuwen ^[2] ; Laura,de Rooij ^[1] ; Joanna,Kalucka ^[2] ; Rongyuan,Chen ^[1] ; Shawez,Khan ^[2] ; Federico,Taverna ^[1] ; Weisi,Lu ^[2] ; Magdalena,Parys ^[1] ; Carla,De Legher ^[2] ; Stefan,Vinckier ^[1] ; Tobias K,Karakach ^[2] ; Luc,Schoonjans ^[1] ; Lin,Lin ^[2] ; Lars,Bolund ^[3] ; Mieke,Dewerchin ^[1] ; Guy,Eelen ^[2] ; Ton J,Rabelink ^[1] ; Xuri,Li ^[2] ; Yonglun,Luo ^[3] ; Peter,Carmeliet ^[1]

作者单位： Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium. ^[1] Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium. ^[2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China. ^[3] Lars Bolund Institute of Regenerative Medicine, Beijing Genomics Institute (BGI)-Qingdao, BGI-Shenzhen, Qingdao, China. ^[4] Department of Biomedicine, Aarhus University, Aarhus, Denmark. ^[5] Division of Nephrology, Department of Internal Medicine, The Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. ^[6] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China; peter.carmeliet@kuleuven.vib.be alun@biomed.au.dk. ^[7] Lars Bolund Institute of Regenerative Medicine, Beijing Genomics Institute (BGI)-Qingdao, BGI-Shenzhen, Qingdao, China; peter.carmeliet@kuleuven.vib.be alun@biomed.au.dk. ^[8] China National GeneBank, Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China; and. ^[9] Qingdao-Europe Advanced Institute for Life Sciences, Beijing Genomics Institute (BGI)-Qingdao, Qingdao, China. ^[10] Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium; peter.carmeliet@kuleuven.vib.be alun@biomed.au.dk. ^[11]

关键词 dehydration heterogeneity oxidative phosphorylation renal endothelial cells scRNA-sequencing urine concentration