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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.

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作者单位: Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA. [1] Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia. [2] Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia. [3] RTI International, Research Triangle Park, NC 27709, USA. [4] Brian Michael McKeever, LLC, Lake Ronkonkoma, NY 11779, USA. [5] CGM Pharma, LLC, Fort Washington, PA 19034, USA. [6] Children's Cancer Institute, School of Women's and Children's Health, UNSW, Sydney 2052, Australia; Department of Anatomical Pathology, Prince of Wales Hospital, Sydney, NSW 2031, Australia. [7] School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia. [8] National Cancer Institute, Bethesda, MD 20892, USA. [9] Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW, Sydney 2052, Australia; Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2210, Australia. [10] Syndax Pharmaceuticals, Waltham, MA 02451, USA. [11] Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA. Electronic address: scott_armstrong@dfci.harvard.edu. [12]
DOI 10.1016/j.ccell.2019.11.001
PMID 31821784
发布时间 2020-12-10
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Cancer cell

Cancer cell

2019年36卷6期

660-673.e11页

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