首页> The Journal of biological chemistry> Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma.

Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma.

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第一作者： Vrajesh,Karkhanis

第一单位： Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210.

作者： Vrajesh,Karkhanis ^[1] ; Lapo,Alinari ^[1] ; Hatice Gulcin,Ozer ^[2] ; Jihyun,Chung ^[1] ; Xiaoli,Zhang ^[3] ; Saïd,Sif ^[4] ; Robert A,Baiocchi ^[5]

作者单位： Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210. ^[1] Department of Biomedical Informatics, Ohio State University, Columbus, Ohio 43210. ^[2] Center for Biostatistics, Department of Biomedical Informatics, Ohio State University, Columbus, Ohio 43210. ^[3] Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, P. O. Box 2713, Doha, Qatar ssif@qu.edu.qa. ^[4] Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210 robert.baiocchi@osumc.edu. ^[5]

关键词 Myc (c-Myc)PRMT5 cancer cyclin D1 epigenetics gene regulation histone deacetylase (HDAC)lymphoma microRNA (miRNA)post-translational modification