The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

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第一作者： Yuanming,He

第一单位： Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China; Guangzhou and Guangdong Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou 511436, China.

作者： Yuanming,He ^[1] ; Siyu,Wang ^[2] ; Jiefei,Tong ^[3] ; Shuoyi,Jiang ^[1] ; Ye,Yang ^[4] ; Zubin,Zhang ^[2] ; Yujia,Xu ^[2] ; Yuanying,Zeng ^[5] ; Biyin,Cao ^[6] ; Michael F,Moran ^[3] ; Xinliang,Mao ^[7]

作者单位： Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China; Guangzhou and Guangdong Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou 511436, China. ^[1] Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China. ^[2] Program in Cell Biology, Hospital for Sick Children, Department of Molecular Genetics, University of Toronto, Toronto M5G 0A4, Canada. ^[3] School of Basic Medicine, Nanjing University of Traditional Medicine, Nanjing 210023, China. ^[4] Department of Oncology, Suzhou Municipal Hospital, Suzhou 215100, China. Electronic address: zengyuanying@163.com. ^[5] Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: caobiyin@suda.edu.cn. ^[6] Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China; Guangzhou and Guangdong Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou 511436, China; Guangzhou Institute of Cardiovascular Disease and Department of Hematology, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China. Electronic address: xinliangmao@suda.edu.cn. ^[7]

关键词 anticancer drug cancer deubiquitylation (deubiquitination)multiple myeloma transcription factor