Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling.

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作者： Vijay Avin,Balaji Ragunathrao ^[1] ; Mumtaz,Anwar ^[1] ; Md Zahid,Akhter ^[1] ; Alejandra,Chavez ^[1] ; De Yu,Mao ^[2] ; Viswanathan,Natarajan ^[3] ; Sribalaji,Lakshmikanthan ^[4] ; Magdalena,Chrzanowska-Wodnicka ^[4] ; Arkadiusz Z,Dudek ^[5] ; Lena,Claesson-Welsh ^[6] ; Jan K,Kitajewski ^[2] ; Kishore K,Wary ^[1] ; Asrar B,Malik ^[1] ; Dolly,Mehta ^[7]

作者单位： Department of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[1] Department of Physiology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[2] Department of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA; Department of Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[3] Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA. ^[4] Department of Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[5] Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden. ^[6] Department of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address: dmehta@uic.edu. ^[7]

关键词 Rac1 S1P S1PR1 VEGF-A VEGFR2 phosphorylation angiogenesis c-Abl1 endothelial cells tumor growth tumor vascularization