Large-Scale Automated Hollow-Fiber Bioreactor Expansion of Umbilical Cord-Derived Human Mesenchymal Stromal Cells for Neurological Disorders.

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作者： Ladislava,Vymetalova ^[1] ; Tereza,Kucirkova ^[1] ; Lucia,Knopfova ^[1] ; Veronika,Pospisilova ^[2] ; Tomas,Kasko ^[3] ; Hana,Lejdarova ^[2] ; Eva,Makaturova ^[3] ; Petr,Kuglik ^[4] ; Veronika,Oralova ^[5] ; Eva,Matalova ^[5] ; Petr,Benes ^[6] ; Zdenek,Koristek ^[7] ; Serhiy,Forostyak ^[7]

作者单位： International Clinical Research Center, St. Anne's University Hospital, Pekarska 53, 656 91, Brno, Czech Republic. ^[1] PrimeCell Bioscience Inc., Dr. Slabihoudka 6232/11, 708 00, Ostrava-Poruba, Czech Republic. ^[2] National Tissue Centre Inc., Palachovo náměstí 726/2, 625 00, Brno, Czech Republic. ^[3] Department of Transfusion & Tissue Medicine, University Hospital Brno, Jihlavska 20, 625 00, Brno, Czech Republic. ^[4] Department of Medical Genetics, University Hospital Brno, 625 00, Brno, Czech Republic. ^[5] Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37, Brno, Czech Republic. ^[6] Institute of Animal Physiology and Genetics, v.v.i, Czech Academy of Sciences, Veveri 97, 602 00, Brno, Czech Republic. ^[7] PrimeCell Bioscience Inc., Dr. Slabihoudka 6232/11, 708 00, Ostrava-Poruba, Czech Republic. Zdenek.Koristek@primecell.eu. ^[8] PrimeCell Advanced Therapy Inc., Palachovo nam. 726/2, 625 00, Brno, Czech Republic. Zdenek.Koristek@primecell.eu. ^[9] PrimeCell Bioscience Inc., Dr. Slabihoudka 6232/11, 708 00, Ostrava-Poruba, Czech Republic. serhiy.forostyak@primecell.eu. ^[10] National Tissue Centre Inc., Palachovo náměstí 726/2, 625 00, Brno, Czech Republic. serhiy.forostyak@primecell.eu. ^[11] PrimeCell Advanced Therapy Inc., Palachovo nam. 726/2, 625 00, Brno, Czech Republic. serhiy.forostyak@primecell.eu. ^[12]

关键词 Bioreactor Good manufacturing practice (GMP)Large-scale expansion Mesenchymal stromal cells Umbilical cord tissue