Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case.

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第一作者： Douglas G,Johns

第一单位： Department of Translational Pharmacology Merck & Co., Inc. Kenilworth NJ USA.

作者： Douglas G,Johns ^[1] ; Sheng-Ping,Wang ^[2] ; Raymond,Rosa ^[2] ; James,Hubert ^[2] ; Suoyu,Xu ^[3] ; Ying,Chen ^[2] ; Thomas,Bateman ^[3] ; Robert O,Blaustein ^[4]

作者单位： Department of Translational Pharmacology Merck & Co., Inc. Kenilworth NJ USA. ^[1] Department of Cardiometabolic Diseases/Atherosclerosis Merck & Co., Inc. Kenilworth NJ USA. ^[2] Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism Merck & Co., Inc. Kenilworth NJ USA. ^[3] Department of Clinical Research Merck & Co., Inc. Kenilworth NJ USA. ^[4]

关键词 adipose anacetrapib cholesteryl ester transfer protein pharmacokinetics

主题词脂肪组织, 白色(Adipose Tissue, White);动物(Animals);热量限制(Caloric Restriction);胆固醇酯转运蛋白质类(Cholesterol Ester Transfer Proteins);胆固醇, HDL(Cholesterol, HDL);胆固醇, LDL(Cholesterol, LDL);疾病模型, 动物(Disease Models, Animal);人类(Humans);降血脂药物(Hypolipidemic Agents);脂类代谢(Lipid Metabolism);男(雄)性(Male);小鼠(Mice);肥胖症(Obesity);恶唑烷酮类(Oxazolidinones);组织分布(Tissue Distribution);体重减轻(Weight Loss)

DOI 10.1002/prp2.543

PMID 31832204

发布时间 2023-10-19

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Pharmacology research & perspectives

2019年7卷6期

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Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case.

Pharmacology research & perspectives

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Pharmacology research & perspectives

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Impact of drug distribution into adipose on tissue function: The cholesteryl ester transfer protein (CETP) inhibitor anacetrapib as a test case.

Pharmacology research & perspectives

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Pharmacology research & perspectives

相关期刊

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