Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.

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第一作者： Lauren M,Gittings

第一单位： Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.

作者： Lauren M,Gittings ^[1] ; Steven,Boeynaems ^[2] ; Daniel,Lightwood ^[3] ; Alison,Clargo ^[4] ; Sarfaraj,Topia ^[5] ; Lisa,Nakayama ^[5] ; Claire,Troakes ^[5] ; David M A,Mann ^[4] ; Aaron D,Gitler ^[6] ; Tammaryn,Lashley ^[7] ; Adrian M,Isaacs ^[4]

作者单位： Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK. ^[1] UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK. ^[2] Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. ^[3] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. ^[4] UCB Pharma, 216 Bath Road, Slough, SL1 3WE, UK. ^[5] London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. ^[6] Division of Neuroscience and Experimental Psychology, School of Biological Sciences, University of Manchester, Salford Royal Hospital, Salford, UK. ^[7] Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK. a.isaacs@ucl.ac.uk. ^[8] UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK. a.isaacs@ucl.ac.uk. ^[9]

主题词肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);精氨酸(Arginine);DNA重复序列扩增(DNA Repeat Expansion);额颞叶变性(Frontotemporal Lobar Degeneration);人类(Humans);甲基化(Methylation)

DOI 10.1007/s00401-019-02104-x

PMID 31832771

发布时间 2021-01-12

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