Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function.

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第一作者： Daisuke,Miyatake

第一单位： Astellas Pharma Inc, Tokyo, Japan.

作者： Daisuke,Miyatake ^[1] ; Tomohisa,Shibata ^[1] ; Junko,Toyoshima ^[1] ; Yuichiro,Kaneko ^[1] ; Kazuo,Oda ^[2] ; Tetsuya,Nishimura ^[1] ; Masataka,Katashima ^[1] ; Masashi,Sakaki ^[3] ; Kazuaki,Inoue ^[4] ; Takayoshi,Ito ^[5] ; Naoki,Uchida ^[6] ; Kenichi,Furihata ^[7] ; Akinori,Urae ^[8]

作者单位： Astellas Pharma Inc, Tokyo, Japan. ^[1] Astellas Research Institute of America LLC, Northbrook, Illinois, USA. ^[2] Showa University School of Medicine, Tokyo, Japan. ^[3] Showa University Fujigaoka Hospital, Yokohama, Japan. ^[4] Showa University Koto Toyosu Hospital, Tokyo, Japan. ^[5] Clinical Research Institute of Clinical Pharmacology and Therapeutics, Showa University, Tokyo, Japan. ^[6] P-One Clinic, Keikokai Medical Corporation, Tokyo, Japan. ^[7] Mediscience Planning, Inc, Tokyo, Japan. ^[8]

关键词 ASP015K Janus kinase inhibitor hepatic impairment peficitinib pharmacokinetics

主题词金刚烷(Adamantane);投药, 口服(Administration, Oral);老年人(Aged);曲线下面积(Area Under Curve);女(雌)性(Female);人类(Humans);肝疾病(Liver Diseases);肝功能试验(Liver Function Tests);男(雄)性(Male);中年人(Middle Aged);烟酰胺(Niacinamide);疾病严重程度指数(Severity of Illness Index)

DOI 10.1002/cpdd.751

PMID 31833184

发布时间 2022-12-07

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Clinical pharmacology in drug development

2020年9卷6期

699-708页

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Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function.

Clinical pharmacology in drug development

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Clinical pharmacology in drug development

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Pharmacokinetics and Safety of a Single Oral Dose of Peficitinib (ASP015K) in Japanese Subjects With Normal and Impaired Hepatic Function.

Clinical pharmacology in drug development

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Clinical pharmacology in drug development

相关期刊

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