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Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML.

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第一作者： Silvia,Masciarelli

第一单位： Section of Histology & Medical Embryology, Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.;Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Rome, Italy.;Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

作者： Silvia,Masciarelli ^[1] ; Ernestina,Capuano ^[2] ; Tiziana,Ottone ^[3] ; Mariadomenica,Divona ^[4] ; Serena,Lavorgna ^[4] ; Francesca,Liccardo ^[2] ; Martyna,Śniegocka ^[2] ; Serena,Travaglini ^[4] ; Nelida I,Noguera ^[3] ; Alessandra,Picardi ^[5] ; Vincenzo,Petrozza ^[6] ; Alessandro,Fatica ^[7] ; Luca,Tamagnone ^[8] ; Maria Teresa,Voso ^[3] ; Francesco,Lo Coco ^[4] ; Francesco,Fazi ^[2]

作者单位： Section of Histology & Medical Embryology, Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.;Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Rome, Italy.;Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. ^[1] Section of Histology & Medical Embryology, Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Sapienza University of Rome, laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. ^[2] Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.;Laboratorio di Neuro-Oncoematologia, Fondazione Santa Lucia, Rome, Italy. ^[3] Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. ^[4] Stem Cell Transplant Unit, Rome Transplant Network, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; and. ^[5] Department of Medico-Surgical Sciences and Biotechnologies and. ^[6] Department of Biology and Biotechnology "C. Darwin," Sapienza University of Rome, Rome, Italy. ^[7] Istituto di Istologia ed Embriologia, Università Cattolica del Sacro Cuore, Rome, Italy.;Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. ^[8]

医学主题词细胞死亡(Cell Death);细胞系, 肿瘤(Cell Line, Tumor);基因复制(Gene Duplication);人类(Humans);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);氧化性应激(Oxidative Stress);串联重复序列(Tandem Repeat Sequences);维甲酸(Tretinoin);非折叠蛋白质应答(Unfolded Protein Response);fms样酪氨酸激酶3(fms-Like Tyrosine Kinase 3)

DOI 10.1182/bloodadvances.2019000540

PMID 31834935

发布时间 2020-09-15

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Blood advances

2019年3卷24期

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2019年3卷24期

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Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML.

Blood advances

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Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML.

Blood advances

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Blood advances

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