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Common Secondary and Tertiary Structural Features of Aptamer-Ligand Interaction Shared by RNA Aptamers with Different Primary Sequences.

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第一作者： Muslum,Ilgu

第一单位： Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA.;Aptalogic Inc., Ames, IA 50014, USA.;Department of Biological Sciences, Middle East Technical University, Ankara 06800, Turkey.

作者： Muslum,Ilgu ^[1] ; Shuting,Yan ^[2] ; Ryan M,Khounlo ^[3] ; Monica H,Lamm ^[2] ; Marit,Nilsen-Hamilton ^[4]

作者单位： Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA.;Aptalogic Inc., Ames, IA 50014, USA.;Department of Biological Sciences, Middle East Technical University, Ankara 06800, Turkey. ^[1] Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA. ^[2] Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA. ^[3] Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA.;Aptalogic Inc., Ames, IA 50014, USA. ^[4]

关键词 2-aminopurine (2AP), molecular dynamics aminoglycoside isothermal titration calorimetry neomycin-B RNA aptamer

医学主题词 2-氨基嘌呤(2-Aminopurine);适体, 核苷(Aptamers, Nucleotide);碱基序列(Base Sequence);配体(Ligands);模型, 分子(Models, Molecular);分子动力学模拟(Molecular Dynamics Simulation);核酸构象(Nucleic Acid Conformation)

DOI 10.3390/molecules24244535

PMID 31835789

发布时间 2020-05-05

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