首页> The Journal of biological chemistry> Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer.

导出 OA

翻译打印收藏纠错

第一作者： Mukul,Sherekar

第一单位： NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702.

作者： Mukul,Sherekar ^[1] ; Sae-Won,Han ^[2] ; Rodolfo,Ghirlando ^[3] ; Simon,Messing ^[1] ; Matthew,Drew ^[1] ; Dana,Rabara ^[1] ; Timothy,Waybright ^[1] ; Puneet,Juneja ^[4] ; Hugh,O'Neill ^[5] ; Christopher B,Stanley ^[5] ; Debsindhu,Bhowmik ^[5] ; Arvind,Ramanathan ^[6] ; Sriram,Subramaniam ^[7] ; Dwight V,Nissley ^[1] ; William,Gillette ^[1] ; Frank,McCormick ^[8] ; Dominic,Esposito ^[9]

作者单位： NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702. ^[1] Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158.;Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea. ^[2] Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892. ^[3] Robert P. Apkarian Integrated Electron Microscopy Core, Emory University, Atlanta, Georgia 30322. ^[4] Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830. ^[5] Argonne National Laboratory, Lemont, Illinois 60439. ^[6] Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702.;Department of Biochemistry, Life Sciences Center, University of British Columbia, Vancouver, British Columbia V6T1Z3, Canada. ^[7] NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702.;Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158. ^[8] NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702 dom.esposito@nih.gov. ^[9]

关键词 GTPase Kras (KRAS)GTPase-activating protein (GAP)NF1 Ras protein cancer cell signaling dimerization mitogen-activated protein kinase pathway neurofibromin

医学主题词 HEK293细胞(HEK293 Cells);人类(Humans);神经纤维素1(Neurofibromin 1);蛋白质多聚化(Protein Multimerization);构效关系(Structure-Activity Relationship);ras GTP酶激活蛋白质类(ras GTPase-Activating Proteins)

DOI 10.1074/jbc.RA119.010934

PMID 31836666

发布时间 2025-05-30

基金项目

HHSN261200800001C/CA/NCI NIH HHS/United States HHSN261200800001E/CA/NCI NIH HHS/United States R35 CA197709/CA/NCI NIH HHS/United States

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交