Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells.

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第一作者： Luca,Puzzi

第一单位： Engineering and Architecture Department, University of Trieste, 34127 Trieste, Italy.

作者： Luca,Puzzi ^[1] ; Daniele,Borin ^[1] ; Priyatansh,Gurha ^[2] ; Raffaella,Lombardi ^[3] ; Valentina,Martinelli ^[4] ; Marek,Weiss ^[5] ; Laura,Andolfi ^[6] ; Marco,Lazzarino ^[6] ; Luisa,Mestroni ^[7] ; Ali J,Marian ^[2] ; Orfeo,Sbaizero ^[1]

作者单位： Engineering and Architecture Department, University of Trieste, 34127 Trieste, Italy. ^[1] Centre for Cardiovascular Genetics, Institute of Molecular Medicine at the University of Texas Health Science Centre and Texas Heart Institute, Houston, TX 77030, USA. ^[2] Advanced Biomedical Sciences, Federico II University, 80138 Napoli, Italy. ^[3] International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy. ^[4] Institute of Physics, Faculty of Technical Physics, Poznan University of Technology, Piotrowo 3, 60965 Poznan, Poland. ^[5] CNR-IOM, Area Science Park, 34149 Trieste, Italy. ^[6] Cardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. ^[7]

关键词 AFM PKP2 arrhythmogenic cardiomyopathy cell adhesion focal adhesion intercalated disk microRNA

主题词动物(Animals);细胞黏附(Cell Adhesion);细胞系(Cell Line);细胞骨架(Cytoskeleton);桥粒(Desmosomes);小鼠(Mice);微RNAs(MicroRNAs);心肌(Myocardium);肌细胞, 心脏(Myocytes, Cardiac);斑菲素蛋白质类(Plakophilins)

DOI 10.3390/cells8121639

PMID 31847412

发布时间 2020-09-01

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2019年8卷12期

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Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells.

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Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells.

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