PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.

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作者： Grant T,Corbett ^[1] ; Zemin,Wang ^[1] ; Wei,Hong ^[1] ; Marti,Colom-Cadena ^[2] ; Jamie,Rose ^[2] ; Meichen,Liao ^[1] ; Adhana,Asfaw ^[1] ; Tia C,Hall ^[1] ; Lai,Ding ^[3] ; Alexandra,DeSousa ^[1] ; Matthew P,Frosch ^[4] ; John,Collinge ^[5] ; David A,Harris ^[6] ; Michael S,Perkinton ^[7] ; Tara L,Spires-Jones ^[2] ; Tracy L,Young-Pearse ^[1] ; Andrew,Billinton ^[7] ; Dominic M,Walsh ^[8]

作者单位： Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA. ^[1] Centre for Discovery Brain Sciences and UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH89JZ, UK. ^[2] Program for Interdisciplinary Neuroscience, Brigham and Women's Hospital, Boston, MA, 02115, USA. ^[3] Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA. ^[4] MRC Prion Unit at UCL, UCL Institute of Prion Diseases, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK. ^[5] Department of Biochemistry, Boston University School of Medicine, Boston, MA, 02118, USA. ^[6] Neuroscience, IMED Biotechnology Unit, AstraZeneca, Cambridge, CB21 6GH, UK. ^[7] Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Hale Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA. dwalsh3@bwh.harvard.edu. ^[8]

关键词 Alzheimer’s disease Aβ Dementia with Lewy bodies Prion protein Tau α-Synuclein