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Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity.

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第一作者： Conglei,Li

第一单位： Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

作者： Conglei,Li ^[1] ; Evelyn,Lam ^[1] ; Christian,Perez-Shibayama ^[2] ; Lesley A,Ward ^[1] ; Jianbo,Zhang ^[3] ; Dennis,Lee ^[1] ; Albert,Nguyen ^[1] ; Musaddeque,Ahmed ^[4] ; Emma,Brownlie ^[5] ; Kirill V,Korneev ^[6] ; Olga,Rojas ^[1] ; Tian,Sun ^[1] ; William,Navarre ^[5] ; Housheng Hansen,He ^[4] ; Shan,Liao ^[3] ; Alberto,Martin ^[1] ; Burkhard,Ludewig ^[2] ; Jennifer L,Gommerman ^[7]

作者单位： Department of Immunology, University of Toronto, Toronto, Ontario, Canada. ^[1] Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland. ^[2] Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. ^[3] Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Toronto, Ontario, Canada. ^[4] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. ^[5] Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Department of Immunology, Biological Faculty, Lomonosov Moscow State University, Moscow, Russia. ^[6] Department of Immunology, University of Toronto, Toronto, Ontario, Canada. jen.gommerman@utoronto.ca. ^[7]

医学主题词动物(Animals);粪便(Feces);女(雌)性(Female);免疫, 黏膜(Immunity, Mucosal);免疫球蛋白A(Immunoglobulin A);淋巴结(Lymph Nodes);淋巴毒素β受体(Lymphotoxin beta Receptor);淋巴毒素α(Lymphotoxin-alpha);男(雄)性(Male);肠系膜(Mesentery);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);间质细胞(Stromal Cells)

DOI 10.1126/sciimmunol.aax1027

PMID 31862865

发布时间 2020-07-03

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2019年4卷42期

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Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity.

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Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity.

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