首页> Biochemical and biophysical research communications> THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.

THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.

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第一作者： Jongchan,Hwang

第一单位： School of Integrative and Global Majors, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

作者： Jongchan,Hwang ^[1] ; Md Anwarul,Haque ^[2] ; Hiroyuki,Suzuki ^[3] ; Peter Ten,Dijke ^[4] ; Mitsuyasu,Kato ^[5]

作者单位： School of Integrative and Global Majors, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. ^[1] Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan; Department of Pharmacy, University of Rajshahi, Rajshai, 6205, Bangladesh. ^[2] Department of Experimental Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. ^[3] Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, the Netherlands; Department of Cancer Signaling, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. ^[4] Department of Experimental Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan; Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. Electronic address: mit-kato@md.tsukuba.ac.jp. ^[5]

关键词 NANOG NRBP1 OCT4 SALL4 TSC22 Homologous Gene-1 Tumorsphere