PCDH17 functions as a common tumor suppressor gene in acute leukemia and its transcriptional downregulation is mediated primarily by aberrant histone acetylation, not DNA methylation.

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作者： Le,Thanh Nha Uyen ^[1] ; Yuji,Amano ^[2] ; Lika'a Fasih Y,Al-Kzayer ^[3] ; Noriko,Kubota ^[2] ; Jun,Kobayashi ^[4] ; Yozo,Nakazawa ^[4] ; Kenichi,Koike ^[2] ; Kazuo,Sakashita ^[2]

作者单位： Department of Medical Genetics, Hue University of Medicine and Pharmacy, Hue, Vietnam. ^[1] Department of Pediatrics, Shinshu University School of Medicine, Matsumoto,, Nagano, Japan. ^[2] Department of Microbiology and Immunology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. ^[3] Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan. ^[4] Shinonoi General Hospital, Minami Nagano Center, Nagano, Japan. ^[5] Department of Pediatrics, Shinshu University School of Medicine, Matsumoto,, Nagano, Japan. sakasita@shinshu-u.ac.jp. ^[6] Department of Hematology and Oncology, Nagano Children's Hospital, 3100 Toyoshina, Azumino, Nagano, Japan. sakasita@shinshu-u.ac.jp. ^[7]

关键词 DNA methylation Histone acetylation Leukemia PCDH17 gene Protocadherin