Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I.
作者:
主题词
3-羟酰CoA脱氢酶类(3-Hydroxyacyl CoA Dehydrogenases);抗肿瘤药(Antineoplastic Agents);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);电子传递复合物Ⅰ(Electron Transport Complex I);酶抑制剂(Enzyme Inhibitors);脂肪酸类(Fatty Acids);基因敲除技术(Gene Knockout Techniques);人类(Humans);肺肿瘤(Lung Neoplasms);分子结构(Molecular Structure);分子靶向治疗(Molecular Targeted Therapy);氧化还原(Oxidation-Reduction);氧耗量(Oxygen Consumption);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);蛋白质组学(Proteomics);喹唑啉酮类(Quinazolinones);构效关系(Structure-Activity Relationship);底物特异性(Substrate Specificity)
DOI
10.1021/acschembio.9b00734
PMID
31874028
发布时间
2024-06-07
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ACS chemical biology
158-170页
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