A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer.

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第一作者： Mark,Yarchoan

第一单位： Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

作者： Mark,Yarchoan ^[1] ; Chiung-Yu,Huang ^[1] ; Qingfeng,Zhu ^[1] ; Anna K,Ferguson ^[1] ; Jennifer N,Durham ^[1] ; Robert A,Anders ^[1] ; Elizabeth D,Thompson ^[1] ; Noah S,Rozich ^[1] ; Dwayne L,Thomas ^[1] ; Julie M,Nauroth ^[1] ; Christina,Rodriguez ^[1] ; Arsen,Osipov ^[1] ; Ana,De Jesus-Acosta ^[1] ; Dung T,Le ^[1] ; Adrian G,Murphy ^[1] ; Daniel,Laheru ^[1] ; Ross C,Donehower ^[1] ; Elizabeth M,Jaffee ^[1] ; Lei,Zheng ^[1] ; Nilofer S,Azad ^[1]

作者单位： Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[1]

关键词 PD-1 checkpoint inhibitor colorectal cancer immunotherapy vaccine

主题词成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);癌症疫苗(Cancer Vaccines);结直肠肿瘤(Colorectal Neoplasms);环磷酰胺(Cyclophosphamide);DNA错配修复(DNA Mismatch Repair);女(雌)性(Female);人类(Humans);免疫疗法(Immunotherapy);男(雄)性(Male);中年人(Middle Aged);肿瘤分期(Neoplasm Staging);肿瘤微环境(Tumor Microenvironment)

DOI 10.1002/cam4.2763

PMID 31876399

发布时间 2021-04-23

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Cancer medicine

2020年9卷4期

1485-1494页

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A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer.

Cancer medicine

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Cancer medicine

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A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer.

Cancer medicine

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Cancer medicine

相关期刊

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