Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.

导出 LinkOut

翻译打印收藏纠错

第一作者： Tareq B,Malas

第一单位： Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

作者： Tareq B,Malas ^[1] ; Wouter N,Leonhard ^[1] ; Hester,Bange ^[2] ; Zoraide,Granchi ^[3] ; Kristina M,Hettne ^[1] ; Gerard J P,Van Westen ^[4] ; Leo S,Price ^[2] ; Peter A C,'t Hoen ^[5] ; Dorien J M,Peters ^[6]

作者单位： Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. ^[1] OcellO B.V., Leiden, the Netherlands. ^[2] GenomeScan B.V., Plesmanlaan 1/D, 2333 BZ Leiden, the Netherlands. ^[3] Drug Discovery and Safety, Leiden Academic Center for Drug Research, Einsteinweg 55, 2333 CC, Leiden, the Netherlands. ^[4] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands. ^[5] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: d.j.m.peters@lumc.nl. ^[6]

关键词 3D cyst assay Autosomal dominant polycystic kidney disease Cheminformatics Drug repurposing RNA-Sequencing

主题词动物(Animals);疾病恶化(Disease Progression);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);肾(Kidney);小鼠(Mice);多囊肾, 常染色体显性(Polycystic Kidney, Autosomal Dominant);结果可重复性(Reproducibility of Results);疾病严重程度指数(Severity of Illness Index);信号传导(Signal Transduction)

DOI 10.1016/j.ebiom.2019.11.046

PMID 31879244

发布时间 2021-01-10

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览0

EBioMedicine

2020年51卷

102585页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.

EBioMedicine

相似文献

EBioMedicine

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.

EBioMedicine

相似文献

EBioMedicine

相关期刊

检索历史清除