Method transfer of a near-infrared spectroscopic method for blend uniformity in a poorly flowing and hygroscopic blend.

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作者： Bárbara B,Alvarado-Hernández ^[1] ; James V,Scicolone ^[2] ; Carlos,Ortega-Zuniga ^[3] ; Andrés D,Román-Ospino ^[2] ; Yleana M,Colón-Lugo ^[4] ; Efrain,Aymat ^[4] ; Eric,Sánchez ^[4] ; Fernando J,Muzzio ^[2] ; Rodolfo J,Romañach ^[5]

作者单位： Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemistry, The University of Puerto Rico at Mayaguez, Puerto Rico, 00681, United States. ^[1] Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemical and Biochemical Engineering, Rutgers University, NJ, Piscataway, 08854, United States. ^[2] Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemistry, The University of Puerto Rico at Mayaguez, Puerto Rico, 00681, United States; Janssen Supply Chain, Johnson & Johnson, Gurabo, Puerto Rico. ^[3] Janssen Supply Chain, Johnson & Johnson, Gurabo, Puerto Rico. ^[4] Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemistry, The University of Puerto Rico at Mayaguez, Puerto Rico, 00681, United States. Electronic address: rodolfoj.romanach@upr.edu. ^[5]

关键词 Blend uniformity analysis Method transfer Multivariate data analysis Partial Least Squares (PLS) regression Powder flow Process analytical technology (PAT)Theory of sampling