Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.

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第一作者： Johannes,Ommer

第一单位： Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

作者： Johannes,Ommer ^[1] ; Joanna L,Selfe ^[2] ; Marco,Wachtel ^[1] ; Eleanor M,O'Brien ^[2] ; Dominik,Laubscher ^[1] ; Michaela,Roemmele ^[1] ; Stephanie,Kasper ^[1] ; Olivier,Delattre ^[3] ; Didier,Surdez ^[3] ; Gemma,Petts ^[4] ; Anna,Kelsey ^[4] ; Janet,Shipley ^[2] ; Beat W,Schäfer ^[5]

作者单位： Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. ^[1] Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom. ^[2] France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France. ^[3] Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom. ^[4] Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. Beat.schaefer@kispi.uzh.ch. ^[5]