The clock gene <i>Bmal1</i> inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.

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第一作者： Gareth B,Kitchen

第一单位： Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.

作者： Gareth B,Kitchen ^[1] ; Peter S,Cunningham ^[2] ; Toryn M,Poolman ^[1] ; Mudassar,Iqbal ^[3] ; Robert,Maidstone ^[4] ; Matthew,Baxter ^[1] ; James,Bagnall ^[3] ; Nicola,Begley ^[4] ; Ben,Saer ^[3] ; Tracy,Hussell ^[4] ; Laura C,Matthews ^[1] ; David H,Dockrell ^[1] ; Hannah J,Durrington ^[1] ; Julie E,Gibbs ^[1] ; John F,Blaikley ^[5] ; Andrew S,Loudon ^[6] ; David W,Ray ^[1]

作者单位： Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom. ^[1] Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom. ^[2] National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom. ^[3] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom. ^[4] Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, LS9 7TF Leeds, United Kingdom. ^[5] Department of Infection Medicine and Medical Research Council Centre for Inflammation Research, University of Edinburgh, EH16 4TJ Edinburgh, United Kingdom. ^[6] Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk. ^[7] National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom; john.blaikley@manchester.ac.uk andrew.loudon@manchester.ac.uk David.Ray@ocdem.ox.ac.uk. ^[8]

关键词 RhoA Streptococcus pneumoniae actin cytoskeleton circadian phagocytosis