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The Dynamics of Cytoplasmic mRNA Metabolism.

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第一作者： Timothy J,Eisen

第一单位： Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

作者： Timothy J,Eisen ^[1] ; Stephen W,Eichhorn ^[1] ; Alexander O,Subtelny ^[1] ; Kathy S,Lin ^[2] ; Sean E,McGeary ^[1] ; Sumeet,Gupta ^[3] ; David P,Bartel ^[4]

作者单位： Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[1] Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[2] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. ^[3] Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: dbartel@wi.mit.edu. ^[4]

关键词 5-ethynyl uridine PAL- seq TAIL-seq deadenylation rates decapping rates mRNA decay rates mRNA uridylation metabolic labeling poly(A)-tail lengths

医学主题词 3T3细胞(3T3 Cells);动物(Animals);细胞质(Cytoplasm);小鼠(Mice);RNA稳定性(RNA Stability);RNA, 信使(RNA, Messenger)

DOI 10.1016/j.molcel.2019.12.005

PMID 31902669

发布时间 2022-04-29

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