Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

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作者： Christopher R,Wellaway ^[1] ; Dominique,Amans ^[1] ; Paul,Bamborough ^[1] ; Heather,Barnett ^[1] ; Rino A,Bit ^[1] ; Jack A,Brown ^[1] ; Neil R,Carlson ^[2] ; Chun-Wa,Chung ^[1] ; Anthony W J,Cooper ^[1] ; Peter D,Craggs ^[1] ; Robert P,Davis ^[1] ; Tony W,Dean ^[1] ; John P,Evans ^[1] ; Laurie,Gordon ^[1] ; Isobel L,Harada ^[1] ; David J,Hirst ^[1] ; Philip G,Humphreys ^[1] ; Katherine L,Jones ^[1] ; Antonia J,Lewis ^[1] ; Matthew J,Lindon ^[1] ; Dave,Lugo ^[1] ; Mahnoor,Mahmood ^[1] ; Scott,McCleary ^[1] ; Patricia,Medeiros ^[2] ; Darren J,Mitchell ^[1] ; Michael,O'Sullivan ^[1] ; Armelle,Le Gall ^[1] ; Vipulkumar K,Patel ^[1] ; Chris,Patten ^[1] ; Darren L,Poole ^[1] ; Rishi R,Shah ^[1] ; Jane E,Smith ^[1] ; Kayleigh A J,Stafford ^[1] ; Pamela J,Thomas ^[1] ; Mythily,Vimal ^[1] ; Ian D,Wall ^[1] ; Robert J,Watson ^[1] ; Natalie,Wellaway ^[1] ; Gang,Yao ^[2] ; Rab K,Prinjha ^[1]

作者单位： GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K. ^[1] GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States. ^[2]