首页> Nature genetics> RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons.

RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons.

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第一作者： James D,Thomas

第一单位： Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

作者： James D,Thomas ^[1] ; Jacob T,Polaski ^[1] ; Qing,Feng ^[1] ; Emma J,De Neef ^[2] ; Emma R,Hoppe ^[2] ; Maria V,McSharry ^[3] ; Joseph,Pangallo ^[1] ; Austin M,Gabel ^[4] ; Andrea E,Belleville ^[5] ; Jacqueline,Watson ^[6] ; Naomi T,Nkinsi ^[3] ; Alice H,Berger ^[7] ; Robert K,Bradley ^[8]

作者单位： Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ^[1] Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Genome Sciences, University of Washington, Seattle, WA, USA. ^[2] Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ^[3] Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Medical Scientist Training Program, University of Washington, Seattle, WA, USA. ^[4] Medical Scientist Training Program, University of Washington, Seattle, WA, USA. ^[5] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[6] Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.;Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ^[7] Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. rbradley@fredhutch.org.;Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. rbradley@fredhutch.org.;Department of Genome Sciences, University of Washington, Seattle, WA, USA. rbradley@fredhutch.org. ^[8]