Discovery of chemical probes that suppress Wnt/β-catenin signaling through high-throughput screening.

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作者： Kiyoshi,Yamaguchi ^[1] ; Satoru,Nagatoishi ^[2] ; Kouhei,Tsumoto ^[2] ; Yoichi,Furukawa ^[3]

作者单位： Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[1] Project Division of Advanced Biopharmaceutical Science, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[2] Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[3] Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan. ^[4]

关键词 TCF/LEF transcription factor Wnt/β-catenin signaling pathway chemical probe high-throughput screening reporter assay

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);转录因子(Transcription Factors);β连环素(beta Catenin)

DOI 10.1111/cas.14297

PMID 31912579

发布时间 2021-01-10

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准确一般字义偏差语意偏离译文作用小提交