Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

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作者： Adam M,Staffaroni ^[1] ; Lynn,Bajorek ^[1] ; Kaitlin B,Casaletto ^[1] ; Yann,Cobigo ^[1] ; Sheng-Yang M,Goh ^[1] ; Amy,Wolf ^[1] ; Hilary W,Heuer ^[1] ; Fanny M,Elahi ^[1] ; Peter A,Ljubenkov ^[1] ; Reilly,Dever ^[1] ; John,Kornak ^[2] ; Brian,Appleby ^[3] ; Jessica,Bove ^[4] ; Yvette,Bordelon ^[5] ; Patrick,Brannelly ^[6] ; Danielle,Brushaber ^[7] ; Christina,Caso ^[8] ; Giovanni,Coppola ^[5] ; Christina,Dheel ^[9] ; Bradford C,Dickerson ^[10] ; Susan,Dickinson ^[11] ; Sophia,Dominguez ^[12] ; Kimiko,Domoto-Reilly ^[4] ; Kelly,Faber ^[8] ; Jessica,Ferrall ^[13] ; Julie A,Fields ^[14] ; Ann,Fishman ^[15] ; Jamie,Fong ^[16] ; Tatiana,Foroud ^[1] ; Leah K,Forsberg ^[13] ; Ralitza,Gavrilova ^[10] ; Debra,Gearhart ^[10] ; Behnaz,Ghazanfari ^[10] ; Nupur,Ghoshal ^[17] ; Jill,Goldman ^[18] ; Jonathan,Graff-Radford ^[19] ; Neill,Graff-Radford ^[20] ; Ian,Grant ^[21] ; Murray,Grossman ^[10] ; Dana,Haley ^[22] ; Ging-Yuek,Hsiung ^[23] ; Edward D,Huey ^[4] ; David J,Irwin ^[22] ; David T,Jones ^[24] ; Lynne,Jones ^[20] ; Kejal,Kantarci ^[21] ; Anna,Karydas ^[4] ; Daniel I,Kaufer ^[10] ; Diana R,Kerwin ^[25] ; David S,Knopman ^[26] ; Ruth,Kraft ^[1] ; Walter K,Kremers ^[14] ; Walter A,Kukull ^[27] ; Irene,Litvan ^[28] ; Diane,Lucente ^[10] ; Codrin,Lungu ^[10] ; Ian R,Mackenzie ^[7] ; Miranda,Maldonado ^[29] ; Masood,Manoochehri ^[30] ; Scott M,McGinnis ^[11] ; Emily,McKinley ^[31] ; Mario F,Mendez ^[32] ; Bruce L,Miller ^[5] ; Namita,Multani ^[20] ; Chiadi,Onyike ^[11] ; Jaya,Padmanabhan ^[33] ; Alex,Pantelyat ^[5] ; Rodney,Pearlman ^[9] ; Len,Petrucelli ^[1] ; Madeline,Potter ^[17] ; Rosa,Rademakers ^[18] ; Eliana Marisa,Ramos ^[34] ; Katherine P,Rankin ^[11] ; Katya,Rascovsky ^[35] ; Erik D,Roberson ^[36] ; Emily,Rogalski ^[37] ; Pheth,Sengdy ^[13] ; Leslie M,Shaw ^[37] ; Jeremy,Syrjanen ^[9] ; M Carmela,Tartaglia ^[1] ; Nadine,Tatton ^[4] ; Joanne,Taylor ^[33] ; Arthur,Toga ^[38] ; John Q,Trojanowski ^[24] ; Sandra,Weintraub ^[39] ; Ping,Wang ^[7] ; Bonnie,Wong ^[17] ; Zbigniew,Wszolek ^[18] ; Adam L,Boxer ^[12] ; Brad F,Boeve ^[1] ; Joel H,Kramer ^[40] ; Howard J,Rosen ^[39] ; ARTFL/LEFFTDS consortium ^[23]

作者单位： Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA. ^[1] Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. ^[2] Department of Neurology, Case Western Reserve University, Cleveland, OH, USA. ^[3] Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA. ^[5] Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA. ^[6] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. ^[7] Department of Neurology, University of Washington, Seattle, WA, USA. ^[8] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA. ^[9] Department of Neurology, Mayo Clinic, Rochester, MN, USA. ^[10] Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ^[11] Association for Frontotemporal Degeneration, Radnor, PA, USA. ^[12] National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA. ^[13] Department of Neurology, University of North Carolina, Chapel Hill, NC, USA. ^[14] Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA. ^[15] School of Medicine, Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA. ^[16] Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. ^[17] Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. ^[18] Departments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA. ^[19] Department of Neurology, Columbia University, New York, NY, USA. ^[20] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. ^[21] Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. ^[22] Feinberg School of Medicine, Department of Neurology, Northwestern University, Chicago, IL, USA. ^[23] Division of Neurology, Deptartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[24] Department of Radiology, Washington University School of Medicine, Washington University, St. Louis, MO, USA. ^[25] Department of Radiology, Mayo Clinic, Rochester, MN, USA. ^[26] Department of Neurology and Neurotherapeutics, Center for Alzheimer's and Neurodegenerative Diseases, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA. ^[27] Department of Internal Medicine, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA. ^[28] National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, WA, USA. ^[29] Department of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, San Diego, CA, USA. ^[30] National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA. ^[31] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[32] Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA. ^[33] Department of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University, Baltimore, MD, USA. ^[34] School of Medicine, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. ^[35] Bluefield Project, San Francisco, CA, USA. ^[36] Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA. ^[37] Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. ^[38] Perelman School of Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[39] Departments of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering, Laboratory of Neuroimaging (LONI), USC, Los Angeles, CA, USA. ^[40]