A bispecific soluble receptor fusion protein that targets TNF-α and IL-21 for synergistic therapy in inflammatory arthritis.-论文-万方医学网

第一作者： Jin-Sil,Park

第一单位： The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

作者： Jin-Sil,Park ^[1] ; Seok-Ho,Yoo ^[2] ; Mi-Ae,Lim ^[1] ; Jun-Geol,Ryu ^[1] ; Hye-Joa,Oh ^[1] ; Sun-Hee,Hwang ^[1] ; SeungCheon,Yang ^[1] ; Kyung-Ah,Jung ^[1] ; Sunha,Yoon ^[2] ; Bum-Chan,Park ^[2] ; Sung-Hwan,Park ^[1] ; Ho-Youn,Kim ^[3] ; Mi-La,Cho ^[1] ; Young-Woo,Park ^[1]

作者单位： The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ^[1] Y-Biologics, Daejeon, Republic of Korea. ^[2] Divison of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ^[3] Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ^[4] Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ^[5]

主题词动物(Animals);关节炎(Arthritis);血液凝固因子(Blood Coagulation Factors);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);人类(Humans);免疫球蛋白类(Immunoglobulins);白细胞介素1受体拮抗蛋白质(Interleukin 1 Receptor Antagonist Protein);白细胞介素类(Interleukins);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交DBA(Mice, Inbred DBA);骨生成(Osteogenesis);蛋白质工程(Protein Engineering);重组蛋白质类(Recombinant Proteins);Th17细胞(Th17 Cells);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1096/fj.201900816RR

PMID 31914604

发布时间 2020-07-13

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A bispecific soluble receptor fusion protein that targets TNF-α and IL-21 for synergistic therapy in inflammatory arthritis.

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A bispecific soluble receptor fusion protein that targets TNF-α and IL-21 for synergistic therapy in inflammatory arthritis.

FASEB journal

相似文献

FASEB journal

相关期刊

检索历史清除