Biological amplification of low frequency mutations unravels laboratory culture history of the bio-threat agent Francisella tularensis.

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作者： Chinmay,Dwibedi ^[1] ; Pär,Larsson ^[2] ; Jon,Ahlinder ^[2] ; Petter,Lindgren ^[2] ; Kerstin,Myrtennäs ^[2] ; Malin,Granberg ^[2] ; Eva,Larsson ^[2] ; Caroline,Öhrman ^[2] ; Andreas,Sjödin ^[2] ; Per,Stenberg ^[3] ; Mats,Forsman ^[2] ; Anders,Johansson ^[4]

作者单位： Department of Clinical Microbiology, Clinical Bacteriology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-901 85 Umeå, Sweden; Swedish Defense Research Agency, Umeå, Sweden. Electronic address: chinmay.dwibedi@umu.se. ^[1] Swedish Defense Research Agency, Umeå, Sweden. ^[2] Swedish Defense Research Agency, Umeå, Sweden; Department of Ecology and Environmental Science (EMG), Umeå University, Umeå, Sweden. ^[3] Department of Clinical Microbiology, Clinical Bacteriology, and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-901 85 Umeå, Sweden. ^[4]

关键词 Francisella tularensis Genetic variation Microbial forensics Molecular evolution Monomorphic bacteria Source attribution

主题词细菌学技术(Bacteriological Techniques);DNA, 细菌(DNA, Bacterial);土拉热弗朗西丝菌(Francisella tularensis);基因组, 细菌(Genome, Bacterial);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);突变(Mutation);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1016/j.fsigen.2019.102230

PMID 31924594

发布时间 2024-05-18

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