Evaluation of <sup>11</sup>C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats.

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作者： Lisheng,Cai ^[1] ; Jeih-San,Liow ^[2] ; Cheryl L,Morse ^[2] ; Sanjay,Telu ^[2] ; Riley,Davies ^[2] ; Michael P,Frankland ^[2] ; Sami S,Zoghbi ^[2] ; Ken,Cheng ^[3] ; Matthew D,Hall ^[3] ; Robert B,Innis ^[2] ; Victor W,Pike ^[2]

作者单位： Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and lishengcai@mail.nih.gov. ^[1] Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and. ^[2] NCATS Chemical Genomics Center, National Institutes of Health, Rockville, Maryland. ^[3]

关键词 GluN2B NMDA receptor NR2B subunit NR2B-SMe sigma 1

主题词动物(Animals);配体(Ligands);正电子发射断层显像术(Positron-Emission Tomography);大鼠(Rats);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);立体异构现象(Stereoisomerism)

DOI 10.2967/jnumed.119.235143

PMID 31924728

发布时间 2021-12-21

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