Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.

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作者： Heather,Hulme ^[1] ; Elva,Fridjonsdottir ^[2] ; Halla,Gunnarsdottir ^[2] ; Theodosia,Vallianatou ^[2] ; Xiaoqun,Zhang ^[3] ; Henrik,Wadensten ^[2] ; Reza,Shariatgorji ^[1] ; Anna,Nilsson ^[1] ; Erwan,Bezard ^[4] ; Per,Svenningsson ^[3] ; Per E,Andrén ^[5]

作者单位： Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, National Resource for Mass Spectrometry Imaging, Uppsala University, Uppsala, Sweden. ^[1] Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. ^[2] Section of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. ^[3] Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France; Centre National de la Recherche Scientifique, Institut des Maladies Neurodégénératives, Bordeaux, France. ^[4] Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, National Resource for Mass Spectrometry Imaging, Uppsala University, Uppsala, Sweden. Electronic address: per.andren@farmbio.uu.se. ^[5]

关键词 Basal ganglia Dynorphin Enkephalin L-DOPA Mass spectrometry imaging Neuropeptide Parkinson's disease Tachykinin