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pH Biosensing by PI4P Regulates Cargo Sorting at the TGN.

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第一作者： John J H,Shin

第一单位： Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada; MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

作者： John J H,Shin ^[1] ; Peter,Liu ^[2] ; Leslie J,Chan ^[2] ; Azmat,Ullah ^[3] ; Jingxi,Pan ^[4] ; Christoph H,Borchers ^[4] ; John E,Burke ^[5] ; Christopher,Stefan ^[6] ; Gertien J,Smits ^[3] ; Christopher J R,Loewen ^[7]

作者单位： Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada; MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. ^[1] Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. ^[2] Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1018 XH Amsterdam, The Netherlands. ^[3] University of Victoria, Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101-4464 Markham St., Victoria, BC V8Z 7X8, Canada; Department of Biochemistry & Microbiology, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5C2, Canada. ^[4] Department of Biochemistry & Microbiology, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5C2, Canada. ^[5] MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK. ^[6] Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address: christopher.loewen@ubc.ca. ^[7]

关键词 Osh1 PH domains PI4P Tat2 cytoplasmic pH membrane contact sites pH biosensing phosphatidylinositol 4-phosphate sterol trafficking trans-Golgi Network