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Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.

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第一作者： Stephen,Mullin

第一单位： Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, London, United Kingdom.;Institute of Translational and Stratified Medicine, University of Plymouth School of Medicine, Plymouth, United Kingdom.

作者： Stephen,Mullin ^[1] ; Laura,Smith ^[2] ; Katherine,Lee ^[2] ; Gayle,D'Souza ^[3] ; Philip,Woodgate ^[3] ; Josh,Elflein ^[3] ; Jenny,Hällqvist ^[4] ; Marco,Toffoli ^[2] ; Adam,Streeter ^[5] ; Joanne,Hosking ^[5] ; Wendy E,Heywood ^[4] ; Rajeshree,Khengar ^[3] ; Philip,Campbell ^[2] ; Jason,Hehir ^[6] ; Sarah,Cable ^[2] ; Kevin,Mills ^[4] ; Henrik,Zetterberg ^[7] ; Patricia,Limousin ^[2] ; Vincenzo,Libri ^[3] ; Tom,Foltynie ^[2] ; Anthony H V,Schapira ^[2]

作者单位： Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, London, United Kingdom.;Institute of Translational and Stratified Medicine, University of Plymouth School of Medicine, Plymouth, United Kingdom. ^[1] Department of Clinical and Movement Neurosciences, University College London Institute of Neurology, London, United Kingdom. ^[2] NIHR UCLH Clinical Research Facility, University College London Hospitals NHS Foundation Trust, London, United Kingdom. ^[3] Translational Mass Spectrometry Research Group, University College London Institute of Child Health, London, United Kingdom. ^[4] Department of Medical Statistics, University of Plymouth School of Medicine, Plymouth, United Kingdom. ^[5] Neurogenetics Unit, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, London, United Kingdom. ^[6] Department of Neurodegenerative Disease, University College London Institute of Neurology, London, United Kingdom.;UK Dementia Research Institute at University College London, London, United Kingdom.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden.;Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden. ^[7]

主题词老年人(Aged);氨溴索(Ambroxol);葡糖苷酰鞘氨醇酶(Glucosylceramidase);人类(Humans);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);帕金森病(Parkinson Disease);治疗结果(Treatment Outcome)

DOI 10.1001/jamaneurol.2019.4611

PMID 31930374

发布时间 2025-05-30

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JAMA neurology

2020年77卷4期

427-434页

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Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.

JAMA neurology

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JAMA neurology

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Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial.

JAMA neurology

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JAMA neurology

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