Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
第一作者:
Yuanzhou,He
第一单位:
Department of Respiratory Diseases, Tongji Hospital, Key Lab of Pulmonary Diseases of Health Ministry, Key Site of National Clinical Research Center for Respiratory Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
作者:
主题词
动物(Animals);芹菜素(Apigenin);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);基因表达调控(Gene Expression Regulation);高血压, 肺性(Hypertension, Pulmonary);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);Kv1.5钾通道(Kv1.5 Potassium Channel);男(雄)性(Male);线粒体(Mitochondria);肌细胞, 平滑肌(Myocytes, Smooth Muscle);肺动脉(Pulmonary Artery);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)
DOI
10.1016/j.cbi.2020.108942
PMID
31930969
发布时间
2020-03-04
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