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首页> Chemico-biological interactions> Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway.

Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway.

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第一作者： Zhengguo,Qiu

第一单位： Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China.

作者： Zhengguo,Qiu ^[1] ; Kefeng,Wang ^[2] ; Chao,Jiang ^[3] ; Yuqiang,Su ^[1] ; Xiaoying,Fan ^[1] ; Jing,Li ^[1] ; Sha,Xue ^[1] ; Li,Yao ^[4]

作者单位： Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China. ^[1] Department of Endocrinology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China. ^[2] The Third Department of Neurology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. ^[3] Department of Neurology, The Hospital of Xidian Group, Xi'an, Shaanxi, 710077, China. Electronic address: yaoli_neurol@163.com. ^[4]

关键词 Cerebral ischemia/reperfusion (I/R)Inflammation Oxidative stress Oxygen-glucose deprivation/reperfusion (OGD/R) model PI3K/Akt signaling pathway Trigonelline

主题词生物碱类(Alkaloids);动物(Animals);脑缺血(Brain Ischemia);细胞存活(Cell Survival);色酮类(Chromones);葡萄糖(Glucose);海马(Hippocampus);炎症(Inflammation);吗啉类(Morpholines);神经元(Neurons);神经保护药(Neuroprotective Agents);氧化性应激(Oxidative Stress);氧(Oxygen);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);再灌注损伤(Reperfusion Injury);信号传导(Signal Transduction)

DOI 10.1016/j.cbi.2020.108946

PMID 31935362

发布时间 2020-03-04

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