首页> Journal of neurodevelopmental disorders> Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.

Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model.

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第一作者： J L,Lukkes

第一单位： Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. jodiburk@iu.edu.;Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA. jodiburk@iu.edu.

作者： J L,Lukkes ^[1] ; H P,Drozd ^[2] ; S D,Fitz ^[3] ; A I,Molosh ^[3] ; D W,Clapp ^[4] ; A,Shekhar ^[5]

作者单位： Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. jodiburk@iu.edu.;Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA. jodiburk@iu.edu. ^[1] Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.;Program in Medical Neurosciences, Indiana University School of Medicine, Indianapolis, IN, USA. ^[2] Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.;Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA. ^[3] Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.;Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA. ^[4] Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.;Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Indianapolis, IN, 46202, USA.;Program in Medical Neurosciences, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.;Indiana Clinical and Translation Sciences Institute, Indiana University School of Medicine, Indianapolis, IN, USA. ^[5]

关键词 ADHD Alpha 2A-adrenergic receptor agonist Behavioral inhibition Cliff avoidance reaction test Delay discounting Guanfacine Hyperactivity Impulsivity Mouse Neurofibromatosis type 1