The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.

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第一作者： Yu,Xu

第一单位： Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115.

作者： Yu,Xu ^[1] ; Lucas,Cantwell ^[1] ; Andrei I,Molosh ^[2] ; Leigh D,Plant ^[1] ; Dimitris,Gazgalis ^[1] ; Stephanie D,Fitz ^[2] ; Erik T,Dustrude ^[2] ; Yuchen,Yang ^[1] ; Takeharu,Kawano ^[1] ; Sumanta,Garai ^[1] ; Sami F,Noujaim ^[3] ; Anantha,Shekhar ^[4] ; Diomedes E,Logothetis ^[5] ; Ganesh A,Thakur ^[6]

作者单位： Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115. ^[1] Department of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202. ^[2] Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612. ^[3] Department of Psychiatry, Paul and Carole Stark Neurosciences Research Institute, Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202. Electronic address: ashekhar@iu.edu. ^[4] Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115. Electronic address: d.logothetis@northeastern.edu. ^[5] Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, and Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115. Electronic address: g.thakur@northeastern.edu. ^[6]

关键词 GIRK channels PIP2 basolateral amygdala medicinal chemistry neurophysiology phosphoinositide potassium channel small molecule specific activator