Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.

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作者： Simone,Bonazzi ^[1] ; Carleton P,Goold ^[2] ; Audrey,Gray ^[2] ; Noel M,Thomsen ^[1] ; Jill,Nunez ^[1] ; Rajeshri G,Karki ^[1] ; Aakruti,Gorde ^[2] ; Jonathan D,Biag ^[2] ; Hasnain A,Malik ^[1] ; Yingchuan,Sun ^[1] ; Guiqing,Liang ^[3] ; Danuta,Lubicka ^[4] ; Sarah,Salas ^[2] ; Nancy,Labbe-Giguere ^[1] ; Erin P,Keaney ^[1] ; Stephanie,McTighe ^[2] ; Shanming,Liu ^[5] ; Lin,Deng ^[3] ; Grazia,Piizzi ^[1] ; Franco,Lombardo ^[3] ; Doug,Burdette ^[3] ; Jean-Cosme,Dodart ^[2] ; Christopher J,Wilson ^[2] ; Stefan,Peukert ^[1] ; Daniel,Curtis ^[2] ; Lawrence G,Hamann ^[1] ; Leon O,Murphy ^[5]

作者单位： Global Discovery Chemistry , Novartis Institutes for BioMedical Research , 181 Massachusetts Ave , Cambridge , Massachusetts 02139 , United States. ^[1] Neuroscience , Novartis Institutes for BioMedical Research , 22 Windsor Street , Cambridge , Massachusetts 02139 , United States. ^[2] Pharmacokinetic Sciences , Novartis Institutes for BioMedical Research , 250 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States. ^[3] Global Drug Development/Technical Research and Development , Novartis Institutes for BioMedical Research , 700 Main Street , Cambridge , Massachusetts 02139 , United States. ^[4] Chemical Biology and Therapeutics , Novartis Institutes for BioMedical Research , 181 Massachusetts Ave , Cambridge , Massachusetts 02139 , United States. ^[5]