Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor.

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作者： Yu,Cai ^[1] ; Jun,Yu ^[1] ; Ping,Ren ^[1] ; Jianlin,He ^[1] ; Zhipeng,Wu ^[1] ; Kun,Xiao ^[1] ; Hong,Jia ^[1] ; Jian,Wang ^[1] ; Yang,Sai ^[1] ; Guangxiu,Dai ^[1] ; Xiong,Li ^[1] ; Weiguo,Su ^[1] ; Karen,Ngo ^[2] ; Glenda,Castro ^[2] ; Paul D,Acton ^[3] ; Wai-Ping,Fung-Leung ^[2] ; James P,Edwards ^[3] ; Jennifer,Venable ^[2] ; Tadimeti S,Rao ^[2]

作者单位： Hutchison MediPharma, Research and Development Center Pudong Shanghai China. ^[1] Janssen Pharmaceutical R&D, LLC. San Diego CA USA. ^[2] Janssen Pharmaceutical R&D, LLC. Spring House PA USA. ^[3]

关键词 HM5023507 PI3Kδ/γ dual inhibitor collagen‐induced arthritis

主题词投药, 口服(Administration, Oral);动物(Animals);B-淋巴细胞(B-Lymphocytes);细胞, 培养的(Cells, Cultured);I类磷脂酰肌醇3-激酶类(Class I Phosphatidylinositol 3-Kinases);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);人类(Humans);大鼠(Rats);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship);T淋巴细胞(T-Lymphocytes)

DOI 10.1002/prp2.559

PMID 31956418

发布时间 2024-03-27

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Pharmacology research & perspectives

2020年8卷1期

e00559页

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Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor.

Pharmacology research & perspectives

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Pharmacology research & perspectives

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Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor.

Pharmacology research & perspectives

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Pharmacology research & perspectives

相关期刊

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