Synthesis, in-vitro and in-silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors.

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作者： Sherif M H,Sanad ^[1] ; Ahmed A M,Ahmed ^[1] ; Ahmed E M,Mekky ^[2]

作者单位： Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. ^[1] Basic Science Department, Jouf University, Sakaka, Kingdom of Saudi Arabia. ^[2]

关键词 5-(aryldiazenyl)thiazoles in-silico study in-vitro MurB inhibitory activity in-vitro antibacterial activities one-pot three-component protocol structure-activity relationship

主题词抗菌药(Anti-Bacterial Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);大肠杆菌(Escherichia coli);肺炎克雷伯菌(Klebsiella pneumoniae);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);金黄色葡萄球菌(Staphylococcus aureus);变异链球菌(Streptococcus mutans);构效关系(Structure-Activity Relationship);噻唑类(Thiazoles);尿苷二磷酸N-乙酰氨基葡萄糖(Uridine Diphosphate N-Acetylglucosamine)

DOI 10.1002/ardp.201900309

PMID 31967349

发布时间 2020-12-31

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2020年353卷4期

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Synthesis, in-vitro and in-silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors.

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Synthesis, in-vitro and in-silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors.

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