Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells.

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第一作者： James D P,Rhodes

第一单位： Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

作者： James D P,Rhodes ^[1] ; Angelika,Feldmann ^[1] ; Benjamín,Hernández-Rodríguez ^[2] ; Noelia,Díaz ^[2] ; Jill M,Brown ^[3] ; Nadezda A,Fursova ^[1] ; Neil P,Blackledge ^[1] ; Praveen,Prathapan ^[1] ; Paula,Dobrinic ^[1] ; Miles K,Huseyin ^[1] ; Aleksander,Szczurek ^[1] ; Kai,Kruse ^[2] ; Kim A,Nasmyth ^[1] ; Veronica J,Buckle ^[3] ; Juan M,Vaquerizas ^[4] ; Robert J,Klose ^[5]

作者单位： Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. ^[1] Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, 48149 Muenster, Germany. ^[2] MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, UK. ^[3] Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, 48149 Muenster, Germany; MRC London Institute of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address: jmv@mpi-muenster.mpg.de. ^[4] Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address: rob.klose@bioch.ox.ac.uk. ^[5]

关键词 Hi-C Polycomb TADs cohesin gene regulation loop extrusion