PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma.
第一作者:
Federica,Ganci
第一单位:
Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
作者:
主题词
动物(Animals);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);I类磷脂酰肌醇3-激酶类(Class I Phosphatidylinositol 3-Kinases);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);头颈部肿瘤(Head and Neck Neoplasms);人类(Humans);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);突变蛋白质类(Mutant Proteins);预后(Prognosis);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);存活率(Survival Rate);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1078-0432.CCR-19-2485
PMID
31969334
发布时间
2021-09-13
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Clinical cancer research
2956-2971页
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