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Evaluation of Genotypic Antiviral Resistance Testing as an Alternative to Phenotypic Testing in a Patient with DOCK8 Deficiency and Severe HSV-1 Disease.

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第一作者： Amanda M,Casto

第一单位： Department of Medicine, University of Washington, Seattle, Washington, USA.;Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

作者： Amanda M,Casto ^[1] ; Sean C,Stout ^[2] ; Rangaraj,Selvarangan ^[3] ; Alexandra F,Freeman ^[4] ; Brandon D,Newell ^[5] ; Erin D,Stahl ^[6] ; Atif A,Ahmed ^[7] ; Alexander L,Greninger ^[8] ; Dwight E,Yin ^[9]

作者单位： Department of Medicine, University of Washington, Seattle, Washington, USA.;Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. ^[1] Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA. ^[2] Department of Pathology and Laboratory Medicine, Children's Mercy, Kansas City, Missouri, USA.;School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.;Division of Infectious Diseases, Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA. ^[3] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[4] School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.;Division of Dermatology, Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA. ^[5] School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.;Section of Ophthalmology, Department of Surgery, Children's Mercy, Kansas City, Missouri, USA. ^[6] Department of Pathology and Laboratory Medicine, Children's Mercy, Kansas City, Missouri, USA. ^[7] Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA. ^[8] School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.;Division of Infectious Diseases, Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA.;Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA. ^[9]

关键词 DOCK8 deficiency HSV-1 genotypic antiviral resistance immunodeficiency intrahost evolution phenotypic antiviral resistance transmitted resistance