Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction.

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第一作者： Thomas J,Ford

第一单位： British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 9DH, UK.

作者： Thomas J,Ford ^[1] ; David,Corcoran ^[2] ; Sandosh,Padmanabhan ^[3] ; Alisha,Aman ^[1] ; Paul,Rocchiccioli ^[4] ; Richard,Good ^[1] ; Margaret,McEntegart ^[1] ; Janet J,Maguire ^[1] ; Stuart,Watkins ^[4] ; Hany,Eteiba ^[1] ; Aadil,Shaukat ^[4] ; Mitchell,Lindsay ^[1] ; Keith,Robertson ^[4] ; Stuart,Hood ^[5] ; Ross,McGeoch ^[4] ; Robert,McDade ^[4] ; Eric,Yii ^[4] ; Naveed,Sattar ^[4] ; Li-Yueh,Hsu ^[4] ; Andrew E,Arai ^[4] ; Keith G,Oldroyd ^[6] ; Rhian M,Touyz ^[4] ; Anthony P,Davenport ^[1] ; Colin,Berry ^[1]

作者单位： British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 9DH, UK. ^[1] Department of Cardiology, Gosford Hospital, NSW, Australia. ^[2] Faculty of Medicine, University of Newcastle, NSW, Australia. ^[3] West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank G81 4DY, UK. ^[4] Experimental Medicine and Immunotherapeutics, University of Cambridge, Level 6, Addenbrooke's Centre for Clinical Investigation (ACCI), Box 110, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. ^[5] Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ^[6]

关键词 Coronary microvascular dysfunction Endothelin-1 Microvascular angina Precision medicine Single-nucleotide polymorphism Stable angina pectoris

主题词冠状动脉疾病(Coronary Artery Disease);内皮缩血管肽1(Endothelin-1);人类(Humans);微血管性心绞痛(Microvascular Angina);心肌缺血(Myocardial Ischemia);血管收缩(Vasoconstriction)

DOI 10.1093/eurheartj/ehz915

PMID 31972008

发布时间 2024-03-06

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