TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.
作者:
主题词
乙酰辅酶A(Acetyl Coenzyme A);酸中毒(Acidosis);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);结直肠肿瘤(Colorectal Neoplasms);上皮-间质转化(Epithelial-Mesenchymal Transition);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肾肿瘤(Kidney Neoplasms);小鼠(Mice);转化生长因子β1(Transforming Growth Factor beta1);转化生长因子β2(Transforming Growth Factor beta2);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/s41467-019-14262-3
PMID
31974393
发布时间
2021-01-22
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