Intravital optoacoustic and ultrasound bio-microscopy reveal radiation-inhibited skull angiogenesis.

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作者： Héctor,Estrada ^[1] ; Johannes,Rebling ^[1] ; Wolfgang,Sievert ^[2] ; Daniela,Hladik ^[3] ; Urs,Hofmann ^[1] ; Sven,Gottschalk ^[4] ; Soile,Tapio ^[3] ; Gabriele,Multhoff ^[5] ; Daniel,Razansky ^[6]

作者单位： Faculty of Medicine and Institute of Pharmacology and Toxicology, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH, Zurich, Switzerland. ^[1] Center of Translational Cancer Research (TranslaTUM), Technical University of Munich, Germany; Department of Radiation Oncology, Klinikum rechts der Isar, Munich, Germany. ^[2] Institute of Radiation Biology, Helmholtz Center Munich, Neuherberg, Germany. ^[3] Institute of Biological and Medical Imaging (IBMI), Helmholtz Center Munich, Neuherberg, Germany. ^[4] Center of Translational Cancer Research (TranslaTUM), Technical University of Munich, Germany; Department of Radiation Oncology, Klinikum rechts der Isar, Munich, Germany; Institute of Pathology, Technical University of Munich, Germany. ^[5] Faculty of Medicine and Institute of Pharmacology and Toxicology, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH, Zurich, Switzerland; Center of Translational Cancer Research (TranslaTUM), Technical University of Munich, Germany; Institute of Biological and Medical Imaging (IBMI), Helmholtz Center Munich, Neuherberg, Germany. Electronic address: daniel.razansky@uzh.ch. ^[6]

关键词 Bone angiogenesis Image segmentation Optoacoustic microscopy Quantitative vasculature analysis Radiation Skull vasculature Ultrasound microscopy

主题词动物(Animals);小鼠(Mice);显微镜检查(Microscopy);颅骨(Skull)

DOI 10.1016/j.bone.2020.115251

PMID 31978616

发布时间 2021-06-17

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