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Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.

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第一作者： Ines,Müller

第一单位： Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany.

作者： Ines,Müller ^[1] ; Elwira,Strozyk ^[1] ; Sebastian,Schindler ^[1] ; Stefan,Beissert ^[2] ; Htoo Zarni,Oo ^[3] ; Thomas,Sauter ^[4] ; Philippe,Lucarelli ^[4] ; Sebastian,Raeth ^[5] ; Angelika,Hausser ^[5] ; Nader,Al Nakouzi ^[3] ; Ladan,Fazli ^[3] ; Martin E,Gleave ^[3] ; He,Liu ^[6] ; Hans-Uwe,Simon ^[6] ; Henning,Walczak ^[7] ; Douglas R,Green ^[8] ; Jiri,Bartek ^[9] ; Mads,Daugaard ^[3] ; Dagmar,Kulms ^[10]

作者单位： Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany. ^[1] Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany. ^[2] Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada; Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada. ^[3] Systems Biology, Life Science Research Unit, University of Luxembourg, 1511 Luxembourg, Luxembourg. ^[4] Institute of Cell Biology and Immunology and Stuttgart Research Centre Systems Biology, University of Stuttgart, Stuttgart 70569, Germany. ^[5] Institute of Pharmacology, University of Bern, Bern 3010, Switzerland. ^[6] Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London WC1E 6DD, UK. ^[7] Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[8] Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 171 77, Sweden. ^[9] Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden 01307, Germany; Center for Regenerative Therapies Dresden, TU-Dresden, Dresden 01307, Germany. Electronic address: dagmar.kulms@uniklinikum-dresden.de. ^[10]

关键词 G2/M checkpoint USP28 apoptosis cancer caspase-8 p53