Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.

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作者： Julia,Cuellar ^[1] ; Mia,Åstrand ^[2] ; Heli,Elovaara ^[3] ; Annukka,Pietikäinen ^[4] ; Saija,Sirén ^[5] ; Arto,Liljeblad ^[5] ; Gabriela,Guédez ^[6] ; Tiina A,Salminen ^[7] ; Jukka,Hytönen ^[6]

作者单位： Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland julia.cuellar@utu.fi. ^[1] Turku Doctoral Programme of Molecular Medicine, Faculty of Medicine, University of Turku, Turku, Finland. ^[2] Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[3] National Doctoral Programme in Informational and Structural Biology, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[4] Institute of Biomedicine, Faculty of Medicine, University of Turku, Turku, Finland. ^[5] Laboratory of Synthetic Drug Chemistry, Institute of Biomedicine, University of Turku, Turku, Finland. ^[6] Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland. ^[7] Laboratory Division, Clinical Microbiology, Turku University Hospital, Turku, Finland. ^[8]

关键词 ABC transporter family BmpD Borrelia burgdorferi X-ray crystallography immunization ligand-binding assay purine metabolism substrate-binding protein