Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms.

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作者： Rasmus K,Pedersen ^[1] ; Morten,Andersen ^[1] ; Trine A,Knudsen ^[2] ; Zamra,Sajid ^[1] ; Johanne,Gudmand-Hoeyer ^[1] ; Marc J B,Dam ^[1] ; Vibe,Skov ^[2] ; Lasse,Kjaer ^[2] ; Christina,Ellervik ^[3] ; Thomas S,Larsen ^[4] ; Dennis,Hansen ^[5] ; Niels,Pallisgaard ^[6] ; Hans C,Hasselbalch ^[7] ; Johnny T,Ottesen ^[7]

作者单位： Department of Science and Environment, Roskilde University, Roskilde, Denmark. ^[1] Department of Haematology, Zealand University Hospital, Roskilde, Denmark. ^[2] Department of Production, Research, and Innovation, Region Zealand, Sorø, Denmark. ^[3] Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[4] Department of Pathology, Harvard Medical School, Boston, FL, USA. ^[5] Department of Laboratory Medicine, Boston Children's Hospital, Boston, FL, USA. ^[6] Department of Hematology, Odense University Hospital, Odense, Denmark. ^[7] Department of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark. ^[8]

关键词 JAK2V617F kinetics early treatment essential thrombocythemia interferon-alpha2 myeloproliferative neoplasms polycythemia vera primary myelofibrosis

主题词成年人(Adult);老年人(Aged);等位基因(Alleles);女(雌)性(Female);人类(Humans);干扰素α(Interferon-alpha);Janus激酶2(Janus Kinase 2);男(雄)性(Male);中年人(Middle Aged);真性红细胞增多症(Polycythemia Vera);聚乙烯二醇类(Polyethylene Glycols);多态性, 单核苷酸(Polymorphism, Single Nucleotide);原发性骨髓纤维化(Primary Myelofibrosis);前瞻性研究(Prospective Studies);重组蛋白质类(Recombinant Proteins);回顾性研究(Retrospective Studies);血小板增多, 原发性(Thrombocythemia, Essential);时间因素(Time Factors);治疗结果(Treatment Outcome)

DOI 10.1002/cam4.2741

PMID 31991066

发布时间 2021-04-23

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Cancer medicine

2020年9卷6期

2039-2051页

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Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms.

Cancer medicine

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Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms.

Cancer medicine

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Cancer medicine

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